Amazon offers Windows 2003 server instances which work really with their Micro Instance machines - Windows 2003 is relative light on memory usage and the up-to 2 ECU power of the micro is well suited to services which spike in usage rather than continuous load.
If you want to arrange back end service on an array of machines - ones that don't interact with the outside world, maybe that are called by your own servers Windows 2003 on a micro instance is an excellent choice as the pricing at 0.02 cents per hour for on demand means you can get a super machine for about $15 USD a month. Much less if you pay for Reserved Instances.
WIndows 2003 Server will still run Net 4.0 applications which are quite recent (2010), so even now with long term support disappearing from Microsoft I still think they a good bet in some "use-cases" to use Amazon terminology.
The image that I used had Net 4.0 already installed and Service Pack 2. However the IIS configuration was not complete, and it took downloading any patches from Microsoft to get the FTP service working - although that might have been an error on my part. The crucial thing to get IIS working was to run this command. Until then Web Service Extension - ASP.NET v4.0.30319 was missing from the IIS applet.
C:\WINDOWS\Microsoft.NET\Framework\v4.0.30319>aspnet_regiis -i -enable
It chugs away for a while. Then go to IIS and refresh - and voliá you have your Web Service Extension installed.
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